I saw on a website that it is okay for me to take Benadryl, but that doesn't sound right.anyone know if this is ok? I'm 36 weeks pregnant and have SEVERE allergies! Can I take Benadryl while I am pregnant? There has been little study done on the effects of Benadryl during pregnancy. Benadryl is considered a B class medication, which means that there is a reasonable amount of experience with a medication during pregnancy and no reason to believe that it would cause harm to the baby. Prenatal vitamins are safe and important to take when you're pregnant. Ask your health care provider about the safety of taking other vitamins, herbal remedies, and supplements. It has 12.5 mg of Diphenhydramine. (which is 1/2 of an adult dose)It has already helped! Benadryl is also on the list of approved medications from my Doctor. (which is 1/2 of an adult dose)It has already helped! I was just wondering if any of you know if benadryl is ok to take when pregnant? i am itching all over like crazy, have no idea why but it is driving me insane. Is it okay to take benadryl while you are pregnant? I have trouble breathing at night because of my sinus head cold/allergies. I don't noramlly like to take anything medications, but I need some relief. Meilleure réponse: Yes that is safe and is FDA approved to take while pregnant. Here is a list of meds that are safe to take while pregnant. Hope this helps. Best Answer: Yes that is safe and is FDA approved to take while pregnant. Here is a list of meds that are safe to take while pregnant. Hope this helps. References for breastfeeding information. Cerner Multum, Inc. Australian Product Information. O 0 Product Information. Benadryl (diphenhydramine). Benadryl is perfectly safe while pregnant!!! I am 8 weeks pregnant and had to take Benedryl! My doctor told me it's safe for alllllllllll pregnant women.